Evaluation of α , β - unsaturated ketones as antileishmanial agents 2 3
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چکیده
Running Title: 1 Evaluation of α,β-unsaturated ketones as antileishmanial agents 2 3 Miguel A. Vasquez, Eva Iniguez, Umashankar Das, Stephen M. Beverley, Linda J. Herrera, 4 Jonathan R. Dimmock, Rosa A. Maldonado 5 6 Department of Biological Sciences, The University of Texas at El Paso, 500 West University 7 Drive, El Paso, TX 79968, USA; College of Pharmacy and Nutrition, University of 8 Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5C9; Department of Molecular 9 Microbiology, Box 8230, Washington University School of Medicine, 660 South Euclid Ave., 10 St. Louis, MO 63110-1093. 11 12 13 14 15 16 Corresponding author: § Rosa A. Maldonado 17 [email protected] 18 19 20 21 22 23 24 AAC Accepted Manuscript Posted Online 23 March 2015 Antimicrob. Agents Chemother. doi:10.1128/AAC.04056-14 Copyright © 2015, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Evaluation of α,β-unsaturated ketones as antileishmanial agents.
In this study, we assessed the antileishmanial activity of 126 α,β-unsaturated ketones. The compounds NC901, NC884, and NC2459 showed high leishmanicidal activity for both the extracellular (50% effective concentration [EC50], 456 nM, 1,122 nM, and 20 nM, respectively) and intracellular (EC50, 1,870 nM, 937 nM, and 625 nM, respectively) forms of Leishmania major propagated in macrophages, with ...
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